基本信息:
性别:男
学历:博士研究生
职称:讲师
教育背景:
本科 2004.09-2008.07 南昌大学药学院、药学专业、获理学学士学位。 期间在中国科学院上海药物研究所朱大元课题组完成本科毕业实习。
硕士 2008.09-2011.06 南昌大学药学院、药物化学专业、获医学硕士学位。
博士 2012.09-2017.06 山东大学药学院、药物化学专业、获医学博士学位。
工作经历:
讲师 2017.09-至今 济宁医学院医药工程学院
教授课程:药物化学、药物化学实验、天然药物化学
学术研究
1.研究方向:
(1)二型糖尿病:以GPR40为靶标的新型降糖药物研究
(2)糖尿病并发症-伤口难以愈合:MMP9抑制剂的研究
2.发表专利:
(1)张颖杰,闫玉刚,徐文方;TAK-875类似物及其制备方法与应用.(已授权)
(2)张颖杰,徐文方,闫玉刚;手性ND-322,ND-364或ND-364亚砜类似物及其制备方法.(已授权)
3.发表文章:
1.Yan, Yugang; Chen, Xueying; Yang, Xinying; Zhang, Jian; Xu, Wenfang; Zhang, Yingjie, Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorganic & medicinal chemistry 2015, 23 (20), 6632-6640.
2.闫玉刚; 陈雪英; 杨新颖; 徐文方; 张颖杰, G蛋白偶联受体40激动剂TAK-875亚砜类似物的合成,绝对构型确证及生物活性研究. 有机化学2017, 37 (4), 858-865. (封面文章)
3.Zhou, Nan; Yan, Yugang; Liu, Chunxi; Hou, Jinning; Xu, Wenfang; Zhang, Yingjie, Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability. Bioorganic & medicinal chemistry 2017, 25 (17), 4614-4619. (共同第一作者)
4.Yan, Yugang; Tu, Guogang.; Wang, Lingdong; Liu, Jian; Li, Shaohua, 4-Chloro-N-[3-methyl-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)but-yl]benzamid e. Acta crystallographica. Section E, Structure reports online 2010, 66 (Pt 6), o1381.
5.Tu, Guogang; Yan, Yugang; Chen, Xueying; Lv, Qiaoli; Wang, jiaqi; Li, Shaohua, Synthesis and antiproliferative assay of 1,3,4-oxadiazole and 1,2,4-triazole derivatives in cancer cells. Drug discoveries & therapeutics 2013.
6.Feng, Chengtao; Wang, Lingdong; Yan, Yugang; Liu, Jian; Li, Shaohua, Synthesis and antitumor evaluation of some 1,3,4-oxadiazole-2(3H)-thione and 1,2,4-triazole-5(1H)-thione derivatives. Medicinal Chemistry Research 2010, 21 (3), 315-320.
7.Chen, Xueying; Liu, Guoliang; Zhang, Wei; Zhang, Jianing; Yan, Yugang; Dong, Wenqian; Liang, Ershun; Zhang, Yun; Zhang, Mingxiang, Inhibition of MEF2A prevents hyperglycemia-induced extracellular matrix accumulation by blocking Akt and TGF-beta1/Smad activation in cardiac fibroblasts. The international journal of biochemistry & cell biology 2015, 69, 52-61.
8.Chen, Xueying; Lv, Ruijuan; Zhang, Wei; Yan, Yugang; Li, Peng; Dong, Wenqian; Liu, Xue; Liang, Ershun; Tian, Hongliang; Lu, Qinghua; Zhang, Mingxiang, Inhibition of myocyte-specific enhancer factor 2A improved diabetic cardiac fibrosis partially by regulating endothelial-to-mesenchymal transition. Oncotarget 2016, 7 (21), 31053-66.