刘贺个人简介

时间:2024-10-10浏览:10



刘贺,博士,讲师

山东省济宁市太白湖新区荷花路133

邮箱he_liu666@163.com

教育和工作经历

2025.03-至今      济宁医学院,医药工程学院,讲师

2019.09-2024.12 大连理工大学,药物工程,工学博士

2016.09-2019.06 大连医科大学,药物化学,医学硕士

2011.09-2015.06 济宁医学院,药学,理学学士

研究领域与方向

重要功能调控分子的筛选与发现以及药理分子机制研究

代表性论文

 目前以第一作者(含共同)身份在eLifeEuropean Journal of Medicinal ChemistryJournal for ImmunoTherapy of Cancer等国际知名学术期刊发表SCI论文5篇(单篇最高影响因子13.751)。

  1. Liu H (第一作者), Liu M, Tian X, Wang H, Gao J, Li H, Zhao Z, Liu Y, Liu C, Chen X, Yang Y. Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma. Elife. 2023, 12: e80625. (自然指数期刊中科院1, IF=6.4)

  2. Liu H (第一作者), Shen C, Li H, Hou T, Yang Y. Discovery of Potent Covalent CRM1 Inhibitors Via a Customized Structure-Based Virtual Screening Pipeline and Bioassays. J Chem Inf Model. 2024, 64(19):7422-7431. JCR Q1, IF=5.6

  3. Zhang Y, Yao Y, Chen P, Liu Y, Zhang H, Liu H, Liu Y, Xu H, Tian X, Wang Z, Chu P, Zhao D, Liu H (共同一作), Zhang C, Chen S, Zhao Y, Liu C, Yang Y. Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy. J Immunother Cancer. 2020, 8(2):e001247. (BMJ 子刊,JCR Q1, IF=13.751)

  4. Liu H (第一作者), Qu M, Xu L, Han X, Wang C, Shu X, Yao J, Liu K, Peng J, Li Y, Ma X. Design and synthesis of sulfonamide-substituted diphenylpyrimidines (SFA-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B-cell lymphoblastic leukemia. Eur J Med Chem. 2017, 135:60-69. (中科院1, IF=6.7)

  5. Liu H (第一作者), Wu B, Ge Y, Huang J, Song S, Wang C, Yao J, Liu K, Li Y, Li Y, Ma X. Phosphamide-containing diphenylpyrimidine analogues (PA-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with enhanced activity against pancreatic cancer cell lines. Bioorg Med Chem. 2017, 25(24):6313-6321. JCR Q2, IF=3.5

发明专利

一种调节肿瘤免疫并抗肿瘤的复方中药组合物的制备及应用(CN114588195B,已授权,3/4